040/21

43. Which of the following metabolic disorder of phenyl alanine and tyrosine metabolic
pathway does not match to its defective enzyme ?
A) Phenyl ketonuria - Phenyl alanine hydroxylase
8) Tyrosinaemia Type | - Hydrolase
©) Tyrosinaemia Type || - Hydroxylase
D) Alkaptonuria - Homogentisate oxidase

44. A sedentary fifty-year-old man weighing 80 kg requests a physical examination. He
denies any health problems. Routine blood analysis is unremarkable except for plasma
cholesterol of 280 mg/dl. The man refuses drug therapy for his hypercholesterolemia.
Analysis of a one-day dietary recall showed the following :

Kilocalories 3475 kcal Cholesterol 822 mg
Protein 1020 Saturated fat 696
Carbohydrates 383 g Total fat 1659
Fiber-Crude 6g

Changes in which one of the following dietary components would have the greatest
effect in lowering plasma cholesterol ?

A) Cholesterol B) Saturated fat

C) Polyunsaturated fat D) Carbohydrate

45. Pulse field gel electrophoresis separates DNA molecule of size
A) 10-20 bp B) 20-30 kb C) 30-50 kb D) 40-50 bp

46. Amino sugars (Hexosamines) are not the constituents of which one of the following ?
A) Hyaluronic acid B) Chondroitin Sulphate
C) Erythromycin and carbomycin D) Streptomycin

47. Diphtheria toxin inhibits translation by biding with
A) elF-2 B) 40S subunit of ribosome
C) eEF-2 0) 60 5 subunit of ribosome

48. An enzyme of purine metabolism associated with immunodeficiency disease
A) Adenosine deaminase B) Xanthine oxidase
C) PRPP synthetase D) HGPRT

49. Ketone bodies are not utilized or oxidized in which one of the following tissues ?
A) Heart B) Brain C) Liver D) Muscles

A 7