D-Gonadectomy generally 15 best done before puberty because the overall risk for tumor development is 30%
Correct Answer:- Option-D

Question8:-The FALSE statement regarding Congenital Adrenal Hyperplasia is
‏یھ‎ females, the classic forms of CAH (with and without salt wasting) are characterized by genital ambiguity and is most commonly due to 21-hydroxylase deficiency
ಯ of patients with 118-hydroxylase deficiency exhibit hypotension and hypokalemia

C:-Females with the non-classical “late-onset” form of 21-hydroxlyased deficiency have normal external genitalia and present later, during early adolescence with precocious
puberty or ather signs of hyperandragenism such as hirsutism

D:-Diagnosis of 21-hydroxylase deficiency is based on a high serum concentration of 17-OH Progesterone
Correct Answer: 8
‘Question9:
Jatter of gonadotropin secretion from infancy to puberty results primarily from a high sensitivity to low levels of gonadal steroid feedback

'diphasic"

B:-central GABA signaling is one of the factors that restrains GnRH neuronal activity during childhood
Czglutamate signaling may play a role in the resurgence of pulsatile GnRH secretion at the onset of puberty
D-hypothalamic kisspeptin-GPRS4 signaling is a key component of the neurobiologic mechanism that triggers the onset of puberty
Correct Answer:- ೦೧000
Question10:-All are TRUE regarding premature ovarian Insulficiency (PO!) EXCEPT
‘Asn all patients under age 30 with a diagnosis of POI, a karyotype should be obtained
B:-Women with POI should be offered testing for FMRI premutations
೦-೦೧೧ with ۶۵۱ should be screened for antiadrenal antibodies and for antithyroid antibodies
D:-Likelinood of achieving pregnancy after diagnosis of १018 about 60-80% and donor eggs are rarely required for IVF
Correct Answer:- Option-D
Question11:-The FALSE statement regarding PolyCystic Ovarian Syndrome (PCOS) is
கபிர்‌ production is increased severalfold in anovulatory PCOS
B:-Those with PCOS generally exhibit altered GnRH pulse frequency, increased serum LH concentrations and low-normal FSH levels
വിന acts synergistically with LH to perpetuate ovarian androgen production and also inhibits hepatic SHBG production
Di-Insulin resistance due to obesity also causes increased leptinsignalling and increased adiponectin levels, there by decreasing fatty acid oxidation and promoting lipotoxicity
Correct Answer:- Option-D
Question12:-Identify the FALSE statement about Metformin
‘Ac Metformin increases insulin sensitivity up to 20% and decreases fasting glucose by about 5%
B:-Metformin decreases weight and 8111 by 3-5%
C-Metformin has no effect on lipolysis and HDL cholesterol
D-Metformin improves the chronic inflammatory state in women with hyperinsulinemia
Correct Answer: Option-C
Question13:-All statements regarding Familial cancers are TRUE EXCEPT
‘Acabout 15-20% of women who develop ovarian cancer have mutations in BRCAL gene
B:-Prophylacticsalpingo-oophorectomy reduces the risk of ovarian cancer by about 90% and the risk of breast cancer by about 50%
C=Risk-reducing salpingo-oophorectomy is recommended at age 35 or when childbearing is complete for patients carrying BRCA mutations and by age 40 in BRCA2 carriers
D:-The use of combined oral contraceptives is likely to reduce the risk of ovarian cancer, but the effect on breast cancer risk is uncertain
Correct Answer:- ೦೧000
Question14:-All are TRUE about Tamoxifen EXCEPT
‘AcTamoxifen is selective estrogen receptor modulator, having both estrogen receptorantagonist and agonist properties, depending on the tissue
B:-The incidence of endometrial cancer quadrupled with 5 years of tamoxifen treatment
C=Levonorgestrel intrauterine device (IUD) is net effective to protect the endometrium against hyperplasia and polyps in women using tamoxifen
D:Tamoxifen is associated with an ultrasonographic image that is characterized by sonolucent changes that are subepithelial in the presence of atrophic epithelium
Correct Answer: Option-C
Question15:-ldentify the FALSE statement about Endometrial Hyperplasia

AcLesions without atypia basically represent only exaggerated forms of persistent proliferative endometrium and are associated with little risk (1-39) for progression to
adenocarcinoma

B-Atypical endometrial hyperplasia does not often spontaneously regress and has significant risk (10-30%) of progression to adenocarcinoma if left untreated
706/9 is significant risk (upto 40%) of an unrecognized adenocarcinoma in endometrial hyperplasia with atypia

D:-Biopsy is not indicated when the clinical history suggests long-term unopposed estrogen exposure but the endometrial thickness is 5-12 mm