D-Gonadectomy generally is best done before puberty because the overall risk for tumor development is 30%
Correct Answer:- Option-D

Question8:-The FALSE statement regarding Congenital Adrenal Hyperplasia is
‘Asn females, the classic forms of CAH (with and without salt wasting) are characterized by genital ambiguity and is most commonly due to 21-hydroxylase deficiency
B:-Two-thirds of patients with 118-hydroxylase deficiency exhibit hypotension and hypokalemia

C:-Females with the non-classical “late-onset” form of 21-hydroxlyased deficiency have normal external genitalia and present later, during early adolescence with precocious
puberty or other signs of hyperandragenism such as hirsutism

D:-Diagnosis of 21-hydroxylase deficiency is based on a high serum concentration of 17-OH Progesterone
Correct Answer: Option ®
(Question9:-The FALSE statement about Puberty in humans is

Jatter of gonadotropin secretion from infancy to puberty results primarily from a high sensitivity to low levels of gonadal steroid feedback

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B:-central GABA signaling is one of the factors that restrains GnRH neuronal activity during childhood
Czglutamate signaling may play a role in the resurgence of pulsatile GnRH secretion at the onset of puberty
D:-hypothalamic kisspeptin-GPRS4 signaling is a key component of the neurobiologic mechanism that triggers the onset of puberty
Correct Answer:- Option-é
Question10:-All are TRUE regarding premature ovarian Insulficiency (PO!) EXCEPT
‘Acnall patients under age 30 with a diagnosis of POI, a karyotype should be obtained
B:-Women with POI should be offered testing for FMRI premutations
‘C:-Women with PO! should be screened for antiadrenal antibodies and for antithyroid antibodies
Ds-Likelinood of achieving pregnancy after diagnosis of १018 about 60-80% and donor eggs are rarely required for IVF
Correct Answer:- Option-D
Question11:-The FALSE statement regarding PolyCystic Ovarian Syndrome (PCOS) is,
[A-AMH production is increased severalfold in anovulatory PCOS
B:-Those with PCOS generally exhibit altered GnRH pulse frequency, increased serum LH concentrations and low-normal FSH levels
டாட synergistically with LH to perpetuate ovarian androgen production and also inhibits hepatic SHBG production
De-Insulin resistance due to obesity also causes increased leptinsignalling and increased adiponectin levels, there by decreasing fatty acid oxidation and promoting lipotoxicity
Correct Answer:- Option-D
Question12:-Identify the FALSE statement about Metformin
‘Ac Metformin increases insulin sensitivity up to 20% and decreases fasting glucose by about 53%
B:-Metformin decreases weight and BMI by 3-5%
CeMetformin has no effect on lipolysis and HDL cholesterol
D-Metformin improves the chronic inflammatory state in women with hyperinsulinemia
Correct Answer:- Option-C
Question13:-All statements regarding Familial cancers are TRUE EXCEPT
‘Acabout 15-20% of women who develop ovarian cancer have mutations in BRCAL gene
B:-Prophylacticsalpingo-oophorectomy reduces the risk of ovarian cancer by about 90% and the risk of breast cancer by about 50%
C=Risk-reducing salpingo-oophorectomy is recommended at age 35 or when childbearing is complete for patients carrying BRCA1 mutations and by age 40 in BRCA2 carriers
D:-The use of combined oral contraceptives is likely to reduce the risk of ovarian cancer, but the effect on breast cancer risk is uncertain
Correct Answer:- Option-é
Question14:-All are TRUE about Tamoxifen EXCEPT
‘AcTamoxifen is selective estrogen receptor modulator, having both estrogen receptorantagonist and agonist properties. depending on the tissue
B:-The incidence of endometrial cancer quadrupled with 5 years of tamoxifen treatment
C=Levonorgestrel intrauterine device (IUD) is not effective to protect the endometrium against hyperplasia and polyps in women using tamoxifen
D:Tamoxifen is associated with an ultrasonographic image that is characterized by sonolucent changes that are subepithelial in the presence of atrophic epithelium
Correct Answer:- Option-C
Question15:-ldentify the FALSE statement about Endometrial Hyperplasia

AcLesions without atypia basically represent only exaggerated forms of persistent proliferative endometrium and are associated with little risk (1-39) for progression to
adenocarcinoma

B-Atypical endometrial hyperplasia does not often spontaneously regress and has significant risk (10-30%) of progression to adenocarcinoma if left untreated
CocThere is significant risk (upto 40%) of an unrecognized adenocarcinoma in endometrial hyperplasia with atypia

D:-Biopsy is not indicated when the clinical history suggests long-term unopposed estrogen exposure but the endometrial thickness is 5-12 mm