Question89:-A 69 years old patient presents with weight loss of 10kg, fatigue and abdominal pain. Investigations show
amass in the right colon, widespread liver metastases and 3 lung nodules. Investigations show Hb 110 g/L, WCC 8x109/I,
alkaline phosphatase 562 U/l, albumin 25. He is unable to continue with his hobby of woodwork but otherwise is self-caring.
Which of the following would influence his management ?

A:-His Hb level, performance status and weight loss
-His performance status weight 1055 and albumin level
C:-His albumin level, alkaline phosphatase and age
D:-His albumin level, weight loss and alkaline phosphatase
Correct Answer:- Option-C
Question90:-STAR trial was for which malignancy ?
A:-Renal cell carcinoma
B:-Breast cancer
C:-Skin cancer
D:-Pancreas cancer
Correct Answer:- Option-A
Question91:-In COMBARZ trial, the drugs compared were
A:-Sorafenib vs Sunitinib
B:-Sunitinib vs Pazopanib
C:-Pazopanib vs Axitinib
D:-Sunitinib vs Sirolimus
Correct Answer:- Option-B
Question92:-Risk of malignancy index incorporates all EXCEPT
A:-USS findings
B:-Pre-operative CA125
C:-Menopausal status
D:-Age
Correct Answer:- Option-D
Question93:-With regard to the traffic light system in the use of Trastuzumb which is wrong

A:-A green light indicates LVEF above the LLN, no signs or symptoms of CHF and any trastuzumab-related LVEF
decrease being <0.10

B:-An amber light indicates LVEF between the LLN and 0.40, with no signs or symptoms of CHF, or a
trastuzumab-related LVEF reduction of 0.1 or more

C:-A red light indicates LVEF <0.40 and symptoms and signs of cardiac failure

D:-Both amber and red are indications for the initiation of ACE inhibitors and referral to cardiology for the optimization
of cardiac function

Correct Answer:- Option-C

Question94:-Which is not a correct match ?
A:-Oct 3/4-Germ cell tumours
B:-Cyclin D1-Mantle cell lymphoma
C:-CD10-Burkitts lymphoma
D:-CK20-Endometrial cancer
Correct Answer:- Option-D

Question95:-In which of the following tumors does survival increase with increasing age ?
A:-Glioblastoma multiforme
B:-Oligodendroglioma
C:-Anaplastic astrocytoma
D:-Brainstem glioma
Correct Answer:- Option-D

Question96:-Deletion of 1p and 19q in oligodendroglioma is associated with
A:-Better response to therapy but similar progression-free and overall survival
B:-Better response to therapy with improved progression-free but similar overall survival
C:-Similar response to therapy with improved progression-free and overall survival
D:-Better response to therapy with improved progression-free and overall survival
Correct Answer:- Option-D

Question97:-All of the following are true regarding the etiology of melanoma, except
A:-Ultraviolet exposure is related to the development of melanoma
B:-Carriers of the CDKN2A mutation have a 70% chance of developing melanoma by age 90
C:-Half of those with melanoma possess the CDKN2A mutation
D:-An increasing number of nevi also increase the risk for melanoma
Correct Answer:- Option-C